Determination of V_{m}and K_{m}## Linear representation of the the Michaelis-Menten Equation

Lineweaver-Burke equationthis equation is written:

where is the change in plasma concentration at a given time interval. S

_{m}is the average plasma concentration between two sampling times.

A plot of versus 1/S

produces a straight line with slope K_{m}_{m}/Vand a y-intercept at 1/V_{m}_{m}.

C.3a-3