## The Michaelis-Menten equation is shown below depicting the

relationship between the rate of elimination of the drug and its concentration.

## If the plasma's concentration is expessed in µg/ml and time in hours, the units are:

V

_{max }(µg/ml)/hK

_{m }µg/ml

## V

_{max}= maximum velocity of the enzyme process; the velocity may approach V_{max }but will never reach it.K

= Michaelis-Menten constant, equal to the concentration at which the rate of the process equals half of the maximum rate._{m}dS/dt = elimination rate of the substrate

dP/dt = rate of product formation

S = substrate

C.3a-2