Repetitive Extravascular Dosing


Example:

In a single IM dose of kanamycin, we obtain the following information: (F=1.0 complete absorption), Vd = 30L, and kel=0.4 hr-1, and the time of the peak is about 1.0hr (ka=4.0hr-1)  If 600-mg doses of kanamycin are administered IM every 4 hr, what will Cmax and Cmin be when the plasma [ ] plateau is reached?

Solution


B.9c-3