Multiple-Dosing Regimens (Repetitive Dosing)

## Graph 1:

## Cmax and Cmin are defined as:

where the maximum and minimum plasma concentrations of a repetitive intravenous dosing regimen can be determined if the dosing interval (

T), the overall elimination rate constant(k_{el}), and the initial plasma concentrationare known. R is the fraction of the initial plasma concentration that remains at the end of any dosing interval.

(for the derivation of Cmin & Cmax for IV dosing)

B.9a-2