Multiple-Dosing Regimens (Repetitive Dosing)


Graph 1:

Cmax and Cmin are defined as:

where the maximum and minimum plasma concentrations of a repetitive intravenous dosing regimen can be determined if the dosing interval (T), the overall elimination rate constant(kel), and the initial plasma concentrationare known.  R is the fraction of the initial plasma concentration that remains at the end of any dosing interval. 

(for the derivation of Cmin & Cmax for IV dosing)


B.9a-2