Repetitive Intravenous Dosing
In repetitive dosing, the plasma concentration at the end of the first dosing interval is given by:
(1) CP1T = CP1Oexp(-kelT)
Immediately after the second dose is injected, the plasma [ ] will be,
(2) CP2O = CP1T + CP1O = CP1Oexp(-kelT) + CP1O and so on.
We then need to define a certain parameter R, which is the fraction of the initial plasma concentration that remains at the end of any dosing interval. R is given as
(3) R = exp(-kelT) = 10-(kelT /2.30)
Equations (1) and (2) are simplified into
CP1T = CP1OR
for the plasma concentration at the end of the first dosing interval, and
CP2O = CP1OR + CP1O
for the plasma concentration at the beginning and end of the nth dosing interval.