MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222 Fall 2014
Instrumentation & Applications for Multimodality Molecular Imaging of Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM Clark S-361

Week Monday Instructor Friday Instructor
1 9/22

Introduction to Molecular Imaging

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

9/26

Nuclear Magnetic Resonance (NMR) and MR Imaging Physics

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

2 9/29

Molecular & Cellular MRI

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

10/3

Radiation/Radionuclide Physics

C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

3 10/6

Tomographic Image Reconstruction

G. Pratx
Lecture notes

Zeng GL. Image reconstruction - a tutorial. Comp Med Imag 2000.

Nuclear Medicine. Mosby, 2006.

Physic in Nuclear Medicine. Saunders. 2012, Chapter 16.

10/10

Positron Emission Tomography (PET)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10

4 10/13

Single Photon Emission Computed Tomography (SPECT)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8

10/17

X-ray Computed Tomography (CT)

R. Fahrig
Lecture notes - Dual Energy CT
Lecture notes - Small Animal CT

Ford NL. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 2003. 30(11): 2869-2877

5 10/20

Multi-modality Molecular Imaging Systems (PET/CT and PET/MRI)

C. Levin
Lecture notes (75MB)

Molecular Imaging: Principles and Practice Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

10/24 MID-TERM EXAM
6 10/27

Visible Light Optics

M. Mandella
Lecture notes 1
Lecture notes 2

Rice BW. In vivo imaging of light-emitting probes. J. Biomed Optics 2001;6(4):432440.

Ntziachristos V. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotech 2005;23(3):313-320.

Troy T. Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models. Mole Img 2004;3(1):9-23.

Weissleder R. Shedding light onto live molecular targets. Nat Med 2003;9(1):123-128.

10/31

Fluorescence Imaging & Tomography

E. Graves
Lecture notes

Patterson MS, et al. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Applied Opt 1989;28(12):2331-36.

Graves EE, et al. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Physics 2003;30(5):901-11.

Ntziachristos V, et al. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett 2001;26(12):893-5.

7 11/3

Bioluminescence Imaging & Tomography

E. Graves
Lecture notes

Contag C, et al. It's Not Just About Anatomy: In Vivo Bioluminescence Imaging as an Eyepiece into Biology. J MRI 2002;16:378-387.

Kuo C, et al. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. Biomed Opt 2007;12(2).

11/7

Ultrasound Imaging Physics

J. Dahl
Lecture notes

Anderson ME. A seminar on k-space applied to medical ultrasound. 1997. Chapters 1 & 2.

Diagnostic Ultrasound Imaging: Inside Out. Academic Press, 2013. Chapter 14 (free to Stanford students)

Dahl J. Ultrasound Beam Forming and Image Formation. RSNA 2005:63-71.

8 11/10

Molecular Ultrasound

J. Willmann
Lecture notes

Deshpande N. Molecular ultrasound imaging: current status and future directions. Clin Radiol. 2010;65(7):567-81.

Pysz MA. Targeted contrast-enhanced ultrasound: an emerging technology in abdominal and pelvic imaging. Gastroent. 2011;140(3):785-90.

Kiessling F. Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics. JNM. 2012;53(3):345-8.

11/14

Photoacoustic Tomography (PAT)

A. de la Zerda

Lecture notes

9 11/17

Optical Fluorescence Endoscopy

C Contag
Lecture notes

Piyawattanametha W. In vivo near-infrared dual-axis confocal microendoscopy in the human lower gastrointestinal tract. JBO 2012;17(2).

Pittet MJ. Intravital Imaging. Cell 2011;147:983-991.

Llewellyn ME. Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans. Nature 2008;454(7):784-788.

Liu JTC. Point-of-care pathology with miniature microscopes. Analytical Cellular Pathology 2011;34:8198.

11/21

Raman Scatter Imaging

C. Zavaleta
Lecture notes

Raman CV, et al. A New Type of Seconday Radiation. Nature 1928.

Zavaleta C, et al. Raman's "Effect" on Molecular Imaging. JNM 2011;52(11):1839-1844.

Thanksgiving recess (11/24-11/28). No class.
10 12/1

Positron Microscopy

G. Pratx
Lecture notes

Pratx G, et al. Radioluminescence Microscopy: Measuring the Heterogeneous Uptake of Radiotracers in Single Living Cells. PLoS One. 2012;7(10):e46285.

Pratx G, et al. High-Resolution Radioluminescence Microscopy of 18F-FDG Uptake by Reconstructing the β-Ionization Track. JNM 2013;54(10):1841-1846.

Vu NT, et al. A β-Camera Integrated with a Microfluidic Chip for Radioassays Based on Real-Time Imaging of Glycolysis in Small Cell Populations. JNM 2011;52(5):815-821.

12/5

X-ray Fluorescence Tomography

L. Xing
Lecture notes A
Lecture notes B
FINAL EXAM
Monday, December 8, 2014 at 8:30-11:30am LK203/204
11 TBD Tours of Small Animal Imaging Facility and Molecular Imaging Clinic
C. Levin

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