MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222 Fall 2014
Instrumentation & Applications for Multimodality Molecular Imaging of Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM Clark S-361

Week Monday Instructor Friday Instructor
1 9/22

Introduction to Molecular Imaging

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

9/26

Nuclear Magnetic Resonance (NMR) and MR Imaging Physics

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

2 9/29

Molecular & Cellular MRI

M. Moseley
Lecture notes

Molecular Imaging Primer. Gambhir SS. 2013 Apple Self-Publishing.

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt I. Principles. Rad. 2012;263(3):633-43

Kircher MF, et al. Molecular body imaging: MR imaging, CT, & US. pt II. Applications. Rad. 2012;263(3):633-43

Torigian DA, et al. PET/MR imaging: technical aspects and potential clinical applications. Rad. 2013;267(1):26-44.

10/3

Radiation/Radionuclide Physics

C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

3 10/6

Tomographic Image Reconstruction

G. Pratx
Lecture notes

Zeng GL. Image reconstruction - a tutorial. Comp Med Imag 2000.

Nuclear Medicine. Mosby, 2006.

Physic in Nuclear Medicine. Saunders. 2012, Chapter 16.

10/10

Positron Emission Tomography (PET)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10

4 10/13

Single Photon Emission Computed Tomography (SPECT)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8

10/17

X-ray Computed Tomography (CT)

R. Fahrig
Lecture notes - Dual Energy CT
Lecture notes - Small Animal CT

Ford NL. Fundamental image quality limits for microcomputed tomography in small animals. Med Phys 2003. 30(11): 2869-2877

5 10/20

Multi-modality Molecular Imaging Systems (PET/CT and PET/MRI)

C. Levin
Lecture notes (75MB)

Molecular Imaging: Principles and Practice Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

10/24 MID-TERM EXAM
6 10/27

Visible Light Optics

M. Mandella
Lecture notes 1
Lecture notes 2

Rice BW. In vivo imaging of light-emitting probes. J. Biomed Optics 2001;6(4):432440.

Ntziachristos V. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotech 2005;23(3):313-320.

Troy T. Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models. Mole Img 2004;3(1):9-23.

Weissleder R. Shedding light onto live molecular targets. Nat Med 2003;9(1):123-128.

10/31

Bioluminescence Imaging & Tomography

E. Graves
7 11/3

Fluorescence Imaging & Tomography

E. Graves
11/7

Ultrasound Imaging Physics

J. Dahl
8 11/10

Molecular Ultrasound

J. Willmann
Lecture notes

Deshpande N. Molecular ultrasound imaging: current status and future directions. Clin Radiol. 2010;65(7):567-81.

Pysz MA. Targeted contrast-enhanced ultrasound: an emerging technology in abdominal and pelvic imaging. Gastroent. 2011;140(3):785-90.

Kiessling F. Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics. JNM. 2012;53(3):345-8.

11/14

Photoacoustic Tomography (PAT)

A. de la Zerda
9 11/17

Optical Fluorescence Endoscopy

C Contag
11/21

Raman Scatter Imaging

C. Zavaleta
Lecture notes

Raman CV, et al. A New Type of Seconday Radiation. Nature 1928.

Zavaleta C, et al. Raman's "Effect" on Molecular Imaging. JNM 2011;52-(11):1839-1844.

Thanksgiving recess (11/24-11/28). No class.
10 12/1

Positron Microscopy

G. Pratx
12/5

X-ray Fluorescence Tomography

L. Xing
FINAL EXAM
Monday, December 8, 2014 at 8:30-11:30am LK203/204
11 TBD Tours of Small Animal Imaging Facility and Molecular Imaging Clinic
C. Levin

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