MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222A Fall 2013
Multi-modality Molecular Imaging in Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM LK 308

Week Monday Instructor Friday Instructor
1 9/23

Introduction to Molecular Imaging

C. Contag
Lecture notes
9/27

Radionuclide Physics

C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

2 9/30

Tomographic Image Reconstruction

C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 20, 21

Alessio A. PET Image Reconstruction. Nuclear Medicine, 2nd Ed.
Bruyant P. Analytic and Iterative Reconstruction Algorithms in SPECT. JNM 2002:43(10).
Germano G. Technical Aspects of Myocardial SPECT Imaging. JNM 2001:42(10).

10/4

Positron Emission Tomography (PET)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10

3 10/7

CCSR 4107

Single Photon Emission Computed Tomography (SPECT)

C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8

10/11

Multi-modality Molecular Imaging Systems (PET/CT and PET/MRI)

C. Levin
Lecture notes (75MB)

Molecular Imaging: Principles and Practice Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

4 10/14

Tissue optics

E. Graves
Lecture notes

Rice BW, et al. In vivo imaging of light-emitting probes. J Biomedical Optics 2001;6(4):432-40.

Ntziachristos V, et al. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotech 2005;23(3):313-320.

Troy T, et al. Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models. Mol Imaging 2004;3(1):9-23.

Weissleder R, et al. Shedding light onto live molecular targets. Nat Med 2003;9(1):123-8.

10/18

Fluorescence Imaging

E. Graves
Lecture notes

Graves EE, et al. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Physics 2003;30(5):901-11.

Ntziachristos V, et al. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett 2001;26(12):893-5.

Patterson MS, et al. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Applied Opt 1989;28(12):2331-36.

5 10/21

LK130

Bioluminescence Imaging

E. Graves
Lecture notes

Kuo C, et al. Three-dimensional reconstruction of in vivo bioluminescent sources based on multispectral imaging. Biomed Opt 2007;12(2).

Contag C, et al. It's Not Just About Anatomy: In Vivo Bioluminescence Imaging as an Eyepiece into Biology. J MRI 2002;16:378-387.

10/25

Raman Scatter Imaging

C. Zavaleta
Lecture notes

Raman CV, et al. A New Type of Seconday Radiation. Nature 1928.

Zavaleta C, et al. Raman's "Effect" on Molecular Imaging. JNM 2011;52-(11):1839-1844.

6 10/28 MID-TERM EXAM 11/1

Ultrasound Imaging

K. Butts Pauly
Lecture notes

Hynynen K. MRIgHIFU: a tool for image-guided therapeutics. JMRI 2011;34(3):482-93.

7 11/4

CCSR 4107

Nuclear Magnetic Resonance (NMR) Physics

M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

11/8

Magnetic Resonance Imaging (MRI)

M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

8 11/11

Photoacoustic Tomography

A. de la Zerda
Lecture notes
11/15

LK208

Technology for Cellular and Molecular MRI

B. Rutt
Lecture notes
9 11/18

Early disease detection and monitoring with ultrasound molecular imaging

J. Willmann
Lecture notes

Deshpande N. Molecular ultrasound imaging: current status and future directions. Clin Radiol. 2010;65(7):567-81.

Pysz MA. Targeted contrast-enhanced ultrasound: an emerging technology in abdominal and pelvic imaging. Gastroent. 2011;140(3):785-90.

Kiessling F. Ultrasound microbubbles for molecular diagnosis, therapy, and theranostics. JNM. 2012;53(3):345-8.

11/22

Molecular Imaging of Cardiac Stem Cell Therapy

P. Nguyen
Lecture notes

Chen IY. Cardiovascular Molecular Imaging: Focus on Clinical Translation. Circ. 2011;123(4):425443.

Nguyen PK. Imaging: Guiding the Clinical Translation of Cardiac Stem Cell Therapy. Circ Res. 2011;109(8):962979.

Additional reading material

Thanksgiving recess (11/25-11/29). No class.
10 12/2

Molecular Imaging of Cancer

Z. Cheng
Lecture notes

Frangioni JV. New technologies for human cancer imagingc. J Clin Oncol. 2008;26(24):4012-21.

Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer. 2002;2(9):683-93.

Vallabhajosula S. A broad overview of positron emission tomography radiopharmaceuticals and clinical applications: what is new?. Semin Nucl Med. 2011;41(4):246-64.

12/6

LK208

Molecular Imaging of the Brain

M. James
Lecture notes

Price JC. Molecular brain imaging in the multimodality era. J Cereb Blood Flow Metab. 2012;32(7):1377-92.

Xi W. Molecular imaging in neuroscience research with small-animal PET in rodents. Neurosci Res. 2011;70(2):133-43.

FINAL EXAM
Wednesday, December 11, 2013 at 8:30-11:30am
CCSR 4205
11 TBD Tours of Small Animal Imaging Facility and Molecular Imaging Clinic
C. Levin

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