MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222C - Spring 2012
Topics in Multimodality Molecular Imaging in Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM
Li Ka Shing Center, LK203/204

Week Monday Instructor Friday Instructor
1 4/2 Multi-modality Imaging of Atherosclerosis
F. Blankenberg
Lecture notes

Cheng VY. Coronary Arterial 18F-FDG Uptake by Fusion of PET and Coronary CT Angiography at Sites of Percutaneous Stenting for Acute Myocardial Infarction and Stable Coronary Artery Disease. JNM 2012;53(3).
Finn AV. Concept of vulnerable/unstable plaque. Arterioscler Thromb Vasc Biol. 2010;30(7).
Motoyama S. Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J Am Coll Cardiol. 2007;50(4).
Ozaki Y. Coronary CT angiographic characteristics of culprit lesions in acute coronary syndromes not related to plaque rupture as defined by optical coherence tomography and angioscopy. Eur Heart J. 2011;32(22).

4/6 Multi-modality Imaging of Atherosclerosis
F. Blankenberg
Lecture notes

Rogers IS. Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina. JACC Cardiovasc Imaging. 2010;3(4).
Ronald JA. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation. 2009;120(7).
Tekabe Y. Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice. J Nucl Cardiol. 2010;17(6).
Zhao Y. Localization of deoxyglucose and annexin A5 in experimental atheroma correlates with macrophage infiltration but not lipid deposition in the lesion. Mol Imaging Biol. 2011;13(4).

2 4/9 Cerenkov luminescence imaging
Z. Cheng
Lecture notes

Liu H. Molecular optical imaging with radioactive probes. PLoS One. 2010;5(3).
Liu H. Radiation-luminescence-excited quantum dots for in vivo multiplexed optical imaging. Small. 2010;6(10).
Robertson R. Optical imaging of Cerenkov light generation from positron-emitting radiotracers. Phys Med Biol. 2009;54(16).
Ruggiero A. Cerenkov luminescence imaging of medical isotopes. JNM 2010;51(7).
Xu Y. Harnessing the power of radionuclides for optical imaging: Cerenkov luminescence imaging. JNM 2011;52(12).

4/13 Cerenkov luminescence imaging
Z. Cheng
Lecture notes
3 4/16 Imaging Metabolidm With Hyperpolarized 13C MRS
D. Spielman
Lecture notes

Brindle KM. Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy. Magn Reson Med. 2011;66(2).
Keshari KR. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. PNAS 2011;108(46).
Malloy CR. Could 13C MRI assist clinical decision-making for patients with heart disease?. NMR Biomed. 2011;24(8).

4/20 Imaging Metabolidm With Hyperpolarized 13C MRS
D. Spielman
Lecture notes
4 4/23 J. Rao

Foster-Gareau P. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med. 2003;49(5).
Liang G. A biocompatible condensation reaction for controlled assembly of nanostructures in living cells. Nat Chem. 2010;2(1).
Sugahara KN. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science. 2010;328(5981).

4/27 J. Rao
5 4/30 Imaging of Neural Activity
L. Xing

Sun C. Synthesis and radioluminescence of PEGylated Eu(3+)-doped nanophosphors as bioimaging probes. Adv Mater. 2011;23(24).
Pratx G. X-ray luminescence computed tomography via selective excitation: a feasibility study. IEEE Trans Med Imaging. 2010;29(12).
Pratx G. Tomographic molecular imaging of x-ray-excitable nanoparticles. Opt Lett. 2010;35(20).

5/4 L. Xing
6 5/7 J. Wu 5/11 J. Wu
7 5/14 S. Plevritis 5/18 S. Plevritis
8 5/21 Imaging of Neural Activity
M. Moseley

Bandettini PA. What's new in neuroimaging methods? Ann N Y Acad Sci. 2009;1156.
van den Bergh E. Diffusion Imaging Syngo REVEAL. Siemens.
Hagmann P. MR connectomics: Principles and challenges. J Neurosci Methods. 2010;194(1).
Hagmann P. Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics. 2006;Suppl 1:S205-23.

5/25 Imaging of Neural Activity
M. Moseley
9 5/29
Imaging Nociception
S. Biswal
6/1 S. Biswal

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