MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222A Fall 2011
Multi-modality Molecular Imaging in Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM, LKSC-LK306

Week Monday Instructor Friday Instructor
1 9/26 Primer on Cellular and Molecular Biology for Imaging
C. Contag
9/30 Primer on Biochemistry for Molecular Imaging
J. Rao
Lecture notes

Molecular Imaging: Principles and Practice Chapter 19

Razgulin A, Maa N and Rao JH. Strategies for in vivo imaging of enzyme activity: an overview and recent advances. Chem Soc Rev 2011;40:41864216.

2 10/3 Radionuclides Physics
C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 4

10/7 Tomographic Image Reconstruction
C. Levin
Lecture notes

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 20, 21

Alessio A. PET Image Reconstruction. Nuclear Medicine, 2nd Ed.
Bruyant P. Analytic and Iterative Reconstruction Algorithms in SPECT. JNM 2002:43(10).
Germano G. Technical Aspects of Myocardial SPECT Imaging. JNM 2001:42(10).

3 10/10 Positron Emission Tomography (PET)
C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 10

10/14 Single Photon Emission Computed Tomography (SPECT) C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Molecular Imaging with Reporter Genes Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapters 7, 8

4 10/17 Multi-modality Molecular Imaging Systems (PET/CT and PET/MRI)
C. Levin
Lecture notes

Molecular Imaging: Principles and Practice Chapter 7

Emission Tomography: The Fundamentals of PET and SPECT. Eds. Wernick and Aarsvold. Elsevier Academic Press, 2004. Chapter 11

10/21 Tissue optics
E. Graves
Lecture notes

Rice BW, et al. In vivo imaging of light-emitting probes. J Biomedical Optics 2001;6(4):432-40.

Ntziachristos V, et al. Looking and listening to light: the evolution of whole-body photonic imaging. Nat Biotech 2005;23(3):313-320.

Troy T, et al. Quantitative Comparison of the Sensitivity of Detection of Fluorescent and Bioluminescent Reporters in Animal Models. Mol Imaging 2004;3(1):9-23.

Weissleder R, et al. Shedding light onto live molecular targets. Nat Med 2003;9(1):123-8.

5 10/24 Fluorescence Imaging
E. Graves
Lecture notes

Patterson MS, et al. Time resolved reflectance and transmittance for the non-invasive measurement of tissue optical properties. Applied Opt 1989;28(12):2331-36.

Graves EE, et al. A submillimeter resolution fluorescence molecular imaging system for small animal imaging. Med Physics 2003;30(5):901-11.

Ntziachristos V, et al. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett 2001;26(12):893-5.

10/28 Bioluminescence Imaging
E. Graves
Lecture notes

Contag C, et al. It's Not Just About Anatomy: In Vivo Bioluminescence Imaging as an Eyepiece into Biology. J MRI 2002;16:378-387.

Kuo C, et al. It's Not Just About Anatomy: In Vivo Bioluminescence Imaging as an Eyepiece into Biology. Biomed Opt 2007;12(2).

6 10/31 Ultrasound Imaging
K. Butts Pauly
Lecture notes
11/4 Nuclear Magnetic Resonance (NMR) Physics
M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

7 11/7 Magnetic Resonance Imaging (MRI)
M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

11/11 MRI Pulse Sequences and Image Reconstruction
M. Moseley
Lecture notes

Molecular Imaging: Principles and Practice Chapter 3, 26, 51, 53-54, 69

8 11/14 Ultrasonic Molecular Imaging: Principles and Applications
J. Willmann
Lecture notes

Deshpande N, et al. Molecular Ultrasound Assessment of Tumor Angiogenesis. Angiogenesis. 2010;13(2):175188.

Willmann J, et al. Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides. JNM 2010;51(3):433-440.

11/18 Cardiovascular Molecular Imaging with MRI
M. McConnell
Lecture notes: CV MRI
Lecture notes: CV Molecular/Cellular Imaging
Thanksgiving recess (11/21-11/25). No class.
9 11/28 Molecular Image Guided Radiation Therapy
L. Xing
Lecture notes
12/2 Technology for cellular and molecular MRI
B. Rutt
Lecture notes
10 12/5 Imaging Pain
S. Biswal
12/9 Molecular Imaging of Cancer using PET
Z. Cheng
Lecture notes

Gambhir SS. Molecular Imaging of Cancer ith Positron Emission Tomography. Nature Revs Cancer. 2002;683-93.

Vallabhajosula S, et al. A Broad Overview of Positron Emission Tomography Radiopharmaceuticals and Clinical Applications: What Is New?. Seminars in Nuc Med. 2011:246264.

FINAL RESEARCH PROPOSALS
Due: December 9, 2011 at 2pm
11 TBD Tours of Small Animal Imaging Facility, Molecular Imaging Clinic, and Radiation Oncology Clinic
C. Levin, L. Xing

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