MIPS Molecular Imaging Program at Stanford

Bioengineering/Radiology 222B - Winter 2011
Chemistry of Molecular Probes for Imaging in Living Subjects

Course Syllabus

CLASSES: Mondays & Fridays 9-10:50 AM, LK 209

Week Monday Instructor Friday Instructor
1 1/3 Overview and reporter proteins
C. Contag
Lecture notes
1/7 Pharmacology and overcoming barriers to delivery
P. Wender
2 1/10 Molecular transporters for delivery of imaging agents
P. Wender
1/14 High throughput screens for finding new probes and targets
F. Cochran
Lecture notes

S Moore, M Olsen, J Cochran and F Cochran. Cell Surface Display Systems for Protein Engineering. Protein Engineering and Design.
F Cochran, J Cochran. Phage display and molecular imaging: expanding fields of vision in living subjects. Biotechnology and Genetic Engineering Reviews 2010;27:57-94.

3 1/17 School holiday: no class 1/21 Peptide probes for imaging
F. Cochran
Lecture notes
4 1/24 Contrast and Contrast Agents in X-ray Imaging
E. Graves

MIPP CH 4: Principles of micro x-ray computed tomography

1/28 Radiochemistry part 1
F. Chin
Lecture notes
5 1/31 Chemical Control of reporters and therapeutic proteins
T. Wandless
Lecture notes

MIPP CH 31: Chemical Biology Approaches to Molecular Imaging

MIPP CH 39: Protein Engineering

2/4 Targeting proteases for imaging
M. Bogyo
Lecture notes

MIPP CH 8: Optical Multimodality

MIPP CH 10: Fluorescence Tomography

MIPP CH 23: Targeted Antibodies and Peptides

MIPP CH 26: Optical Imaging Agents

MIPP CH 31: Chemical Biology Approaches to Molecular Imaging

MIPP CH 47: Fluorescence Reporters/Activatable Cell Penetrating Peptides

MIPP CH 48: Imaging of Signaling Pathways

MIPP CH 49: Molecular and Functional Imaging of the Tumor Microenvironment

MIPP CH 56: Molecular Imaging of Atherosclerosis

MIPP CH 63: Rheumatoid Arthritis

MIPP CH 65: Imaging in Asthma

6 2/7 Radiochemistry part 2
F. Chin
Lecture notes

MIPP CH 20: Radiochemistry of SPECT

MIPP CH 21: Nanochemistry for Molecular Imaging

2/11 Optical reporters - principles
M. Lin
Lecture notes

MIPP CH 26: Optical Imaging Agents

MIPP CH 47: Fluorescence Reporters/Activatable Cell Penetrating Peptides

7 2/14 Optical reporters - practice
M. Lin
Lecture notes
2/18 Novel strategies in optical imaging agents
J. Rao
Lecture notes
8 2/21 School holiday: no class 2/25 Particles and probes
J. Rao
9 2/28 Hyperpolarized compounds for MRI
D. Spielman
Lecture notes

MIPP CH 24: Hyperpolarized 13C magnetic resonance imaging ' Principles and applications

MIPP CH 52: MRS Treatment Response and Detection

3/4 Antibodies and their derivatives as imaging probes
A. Wu
Lecture notes

S Moore, M Olsen, J Cochran and F Cochran. Cell Surface Display Systems for Protein Engineering. Protein Engineering and Design.

MIPP CH 23: Targeted Antibodies and Peptides

MIPP CH 39: Protein Engineering

10 3/7 Novel MRI probes
B. Rutt
Lecture notes
3/11 MRI Probes for cell trafficking
B. Rutt
Lecture notes
Final Presentations: March 18, 2011
Li Ka Shing, 3rd floor - Room LK306

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